human brca2 antibody Search Results


mab2476  (R&D Systems)
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R&D Systems mab2476
Dual C-terminal and N-terminal <t>BRCA2</t> immunohistochemistry (IHC) of hereditary breast cancers (A and B, respectively) and of sporadic breast cancers (C and D, respectively). Magnification is (left) ×20 and (right) ×100 for all panels. The upper panel for each pair is C-terminal IHC, and the lower panel is N-terminal IHC. (A) Samples are from a BRCA2-mutant cancer with 7231del5. Top panel stained with C-terminal BRCA2 antibody, and second panel stained with N-terminal BRCA2 antibody. Only a lymphocyte in the top panel stains. (B) Samples are from a patient with a 9654delTT BRCA2 mutation at similar magnifications and similar staining. (C and D) The paired panels are from adjacent sections of the same sporadic breast cancer sample. Note the similar nuclear staining with both antibodies for the sporadic cancer samples.
Mab2476, supplied by R&D Systems, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mab2476 - by Bioz Stars, 2026-05
93/100 stars
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human brca2 antibody  (R&D Systems)
N/A
The Human BRCA2 Antibody from R D Systems is a mouse monoclonal antibody to BRCA2 This antibody reacts with human The Human BRCA2 Antibody has been validated for the following applications Western Blot Immunohistochemistry
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rcombinant anti-human brca2 antibody fab fragment  (Creative BioMart)
N/A
Recombinant Mouse Antibody Fab Fragment specifically reacts with Human BRCA2, expressed in Chinese Hamster Ovary cells(CHO).Can be useful in applications such as: Radioimmunoassay; Immunofluorescence; Functional StudyStore at -20°C. Open under aseptic conditions.http://www.creativebiolabs.net/Rcombinant-Anti-Human-BRCA2-Antibody-Fab-Fragment-8272.htm
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rcombinant anti-human brca2 antibody scfv fragment  (Creative BioMart)
N/A
Recombinant Mouse Antibody scFv Fragment shows strong binding capacity to Human BRCA2, expressed in E. coli.Can be useful in applications such as: Western blot; Immunoprecipitation; Functional StudyShort Term Storage: 4°CLong Term Storage: -20°Chttp://www.creativebiolabs.net/Rcombinant-Anti-Human-BRCA2-Antibody-scFv-Fragment-8273.htm
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rcombinant anti-human brca2 antibody  (Creative BioMart)
N/A
Recombinant Mouse Antibody shows specific binding activity against Human BRCA2, expressed in Chinese Hamster Ovary cells(CHO).Can be useful in applications such as: Western blot; Immunohistochemistry; Functional StudyStore at – 20 or -70°Cupon receipt. Divide antibody
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Image Search Results


Dual C-terminal and N-terminal BRCA2 immunohistochemistry (IHC) of hereditary breast cancers (A and B, respectively) and of sporadic breast cancers (C and D, respectively). Magnification is (left) ×20 and (right) ×100 for all panels. The upper panel for each pair is C-terminal IHC, and the lower panel is N-terminal IHC. (A) Samples are from a BRCA2-mutant cancer with 7231del5. Top panel stained with C-terminal BRCA2 antibody, and second panel stained with N-terminal BRCA2 antibody. Only a lymphocyte in the top panel stains. (B) Samples are from a patient with a 9654delTT BRCA2 mutation at similar magnifications and similar staining. (C and D) The paired panels are from adjacent sections of the same sporadic breast cancer sample. Note the similar nuclear staining with both antibodies for the sporadic cancer samples.

Journal: Journal of Clinical Oncology

Article Title: Detecting BRCA2 Protein Truncation in Tissue Biopsies to Identify Breast Cancers That Arise in BRCA2 Gene Mutation Carriers

doi: 10.1200/JCO.2008.20.5211

Figure Lengend Snippet: Dual C-terminal and N-terminal BRCA2 immunohistochemistry (IHC) of hereditary breast cancers (A and B, respectively) and of sporadic breast cancers (C and D, respectively). Magnification is (left) ×20 and (right) ×100 for all panels. The upper panel for each pair is C-terminal IHC, and the lower panel is N-terminal IHC. (A) Samples are from a BRCA2-mutant cancer with 7231del5. Top panel stained with C-terminal BRCA2 antibody, and second panel stained with N-terminal BRCA2 antibody. Only a lymphocyte in the top panel stains. (B) Samples are from a patient with a 9654delTT BRCA2 mutation at similar magnifications and similar staining. (C and D) The paired panels are from adjacent sections of the same sporadic breast cancer sample. Note the similar nuclear staining with both antibodies for the sporadic cancer samples.

Article Snippet: The N-terminal antibody used was from R&D systems MAB2476 (a commercially available mouse monoclonal antibody directed against an E coli –derived recombinant human BRCA2 protein that spans amino acids 1-200), which was used at 3 μg/mL.

Techniques: Immunohistochemistry, Mutagenesis, Staining

Immunohistochemistry with 575A15 C-terminal monoclonal antibody on normal breast epithelial lobules. Upper panels: untreated antibody. Middle panels: antibody mixed with excess of immunizing peptide (BRCA2 amino acids 3284 to 3294: TFVSPAAKAGG). Lower panels: antibody mixed with excess of control BRCA2 peptide (BRCA2 amino acids between 3300 and 3400, obtained from Abcam (Cambridge MA). Magnification is (left) ×20 and (right) ×100.

Journal: Journal of Clinical Oncology

Article Title: Detecting BRCA2 Protein Truncation in Tissue Biopsies to Identify Breast Cancers That Arise in BRCA2 Gene Mutation Carriers

doi: 10.1200/JCO.2008.20.5211

Figure Lengend Snippet: Immunohistochemistry with 575A15 C-terminal monoclonal antibody on normal breast epithelial lobules. Upper panels: untreated antibody. Middle panels: antibody mixed with excess of immunizing peptide (BRCA2 amino acids 3284 to 3294: TFVSPAAKAGG). Lower panels: antibody mixed with excess of control BRCA2 peptide (BRCA2 amino acids between 3300 and 3400, obtained from Abcam (Cambridge MA). Magnification is (left) ×20 and (right) ×100.

Article Snippet: The N-terminal antibody used was from R&D systems MAB2476 (a commercially available mouse monoclonal antibody directed against an E coli –derived recombinant human BRCA2 protein that spans amino acids 1-200), which was used at 3 μg/mL.

Techniques: Immunohistochemistry

MCF7 cells were cultured for 48 hours in 10% charcoal-stripped serum/phenol red–free DMEM and were treated with 10 nmol/L estrogen for 5 and 30 minutes and for 1, 2, 4, and 24 hours. Samples were blotted with the 575A15 BRCA2 C-terminal monoclonal antibody. The 440 kDa band is the only band on the blot.

Journal: Journal of Clinical Oncology

Article Title: Detecting BRCA2 Protein Truncation in Tissue Biopsies to Identify Breast Cancers That Arise in BRCA2 Gene Mutation Carriers

doi: 10.1200/JCO.2008.20.5211

Figure Lengend Snippet: MCF7 cells were cultured for 48 hours in 10% charcoal-stripped serum/phenol red–free DMEM and were treated with 10 nmol/L estrogen for 5 and 30 minutes and for 1, 2, 4, and 24 hours. Samples were blotted with the 575A15 BRCA2 C-terminal monoclonal antibody. The 440 kDa band is the only band on the blot.

Article Snippet: The N-terminal antibody used was from R&D systems MAB2476 (a commercially available mouse monoclonal antibody directed against an E coli –derived recombinant human BRCA2 protein that spans amino acids 1-200), which was used at 3 μg/mL.

Techniques: Cell Culture

BRCA2 Mutations Identified in Patients With Breast Cancer

Journal: Journal of Clinical Oncology

Article Title: Detecting BRCA2 Protein Truncation in Tissue Biopsies to Identify Breast Cancers That Arise in BRCA2 Gene Mutation Carriers

doi: 10.1200/JCO.2008.20.5211

Figure Lengend Snippet: BRCA2 Mutations Identified in Patients With Breast Cancer

Article Snippet: The N-terminal antibody used was from R&D systems MAB2476 (a commercially available mouse monoclonal antibody directed against an E coli –derived recombinant human BRCA2 protein that spans amino acids 1-200), which was used at 3 μg/mL.

Techniques: Mutagenesis